Methods and compositions for increasing iduronate 2-sulfatase activity in the CNS
作者： Ruben J. Boado , William M. Pardridge
DOI:
关键词: Blood–brain barrier 、 Iduronate-2-sulfatase activity 、 Systemic administration 、 Chemistry 、 Antibody 、 Immunology
摘要: Provided herein are methods and compositions for treating a subject suffering from deficiency in iduronate 2-sulfatase the CNS. The include systemic administration of bifunctional fusion antibody comprising an that crosses blood brain barrier (BBB) 2-sulfatase.
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