Assessing the outcome of the management of diabetic foot ulcers using ulcer-related and person-related measures

作者: W. J. Jeffcoate , S. Y. Chipchase , P. Ince , F. L. Game

DOI: 10.2337/DC06-0306

关键词: AmputationSepsisSurgeryDiabetes mellitusDiabetic footPeripheral neuropathyCohort studyCohortMedicineComplication

摘要: OBJECTIVE —The purpose of this study was to compare different outcome measures in the audit management diabetic foot ulcers RESEARCH DESIGN AND METHODS —Data collected prospectively a consecutive cohort patients referred specialist multidisciplinary care clinic between 1 January 2000 and 31 December 2003 were analyzed. A single index ulcer selected for each patient classified according both Size (Area Depth), Sepsis, Arteriopathy, Denervation [S(AD)SAD] University Texas (UT) systems. Ulcer-related outcomes (healing, resolution by ipsilateral amputation or death, persisting unhealed) determined at 6 12 months compared with patient-related (survival, any amputation, being free from ulcer) months. RESULTS —In 449 (63.7% male, mean age 66.7 ± 13.2 years), 352 (78.4%) ulcers superficial [S(AD)SAD/UT grade 1] 134 these (38.1% 352) neither ischemic nor infected. total 183 (40.8% 449) clinically infected, peripheral arterial disease present 216 (48.1%). Seventeen (3.8%) lost follow-up excluded analysis. Of ulcers, 247 (55.0% 295 (65.7%) healed without months, respectively. Median (range) time healing 78 (7–364) days. all 5.8 8.0% resolved 6.2 10.9% death same points; 27.8 11.6% persisted unhealed. In contrast, revealed that only 202 (45.0%) alive, months. This group had 272 (1–358) days ulcer. 48 (10.7%) undergone some form 75 (16.7%) died. CONCLUSIONS —These data illustrate extent which ulcer-related may underestimate true morbidity mortality associated disease. It is suggested when attempts are made effectiveness centers, greater emphasis should be placed on measures.

参考文章(9)
Apelqvist J, Wound healing in diabetes. Outcome and costs. Clinics in Podiatric Medicine and Surgery. ,vol. 15, pp. 21- 39 ,(1998)
William J. Jeffcoate, Patricia Price, Keith G. Harding, , Wound healing and treatments for people with diabetic foot ulcers Diabetes-metabolism Research and Reviews. ,vol. 20, ,(2004) , 10.1002/DMRR.476
N. Pound, S. Chipchase, K. Treece, F. Game, W. Jeffcoate, Ulcer‐free survival following management of foot ulcers in diabetes Diabetic Medicine. ,vol. 22, pp. 1306- 1309 ,(2005) , 10.1111/J.1464-5491.2005.01640.X
S. O. Oyibo, E. B. Jude, I. Tarawneh, H. C. Nguyen, L. B. Harkless, A. J.M. Boulton, A Comparison of Two Diabetic Foot Ulcer Classification Systems The Wagner and the University of Texas wound classification systems Diabetes Care. ,vol. 24, pp. 84- 88 ,(2001) , 10.2337/DIACARE.24.1.84
Peter R Cavanagh, Benjamin A Lipsky, Andrew W Bradbury, Georgeanne Botek, Treatment for diabetic foot ulcers The Lancet. ,vol. 366, pp. 1725- 1735 ,(2005) , 10.1016/S0140-6736(05)67699-4
K. A. Treece, R. M. Macfarlane, N. Pound, F. L. Game, W. J. Jeffcoate, Validation of a system of foot ulcer classification in diabetes mellitus Diabetic Medicine. ,vol. 21, pp. 987- 991 ,(2004) , 10.1111/J.1464-5491.2004.01275.X
Andrew JM Boulton, Loretta Vileikyte, Gunnel Ragnarson-Tennvall, Jan Apelqvist, The global burden of diabetic foot disease The Lancet. ,vol. 366, pp. 1719- 1724 ,(2005) , 10.1016/S0140-6736(05)67698-2
Nalini Singh, Preventing Foot Ulcers in Patients With Diabetes JAMA. ,vol. 293, pp. 217- 228 ,(2005) , 10.1001/JAMA.293.2.217