Catalytic oxidation of 4-piperidone-3-carboxylates with manganese(III) acetate in the presence of 1,1-disubstituted alkenes
作者： Ryoukou Kumabe , Hiroshi Nishino , Mikio Yasutake , Van-Ha Nguyen , Kazu Kurosawa
DOI: 10.1016/S0040-4039(00)01884-0
关键词: Crystal structure 、 Hydrogenolysis 、 Medicinal chemistry 、 Catalysis 、 Single crystal 、 Chemistry 、 Manganese 、 Catalytic oxidation 、 Manganese(III) acetate 、 Stoichiometry
摘要: Abstract The manganese(III) acetate-catalyzed cycloperoxidation of 4-piperidone-3-carboxylates with 1,1-disubstituted alkenes is described. reacted in the presence a catalytic amount acetate air at 23°C to give 1-hydroxy-8-aza-2,3-dioxabicyclo[4.4.0]decane-6-carboxylates good moderate yields. crystal structure azabicyclic peroxides was determined by an X-ray single analysis. oxidation 1,1-diphenylethene using stoichiometric gave ethenyl- and ethyl-substituted 4-piperidones 6-hydroxy-3-aza-7-oxabicyclo[4.3.0]nonane-1-carboxylate, which same as product obtained from hydrogenolysis 1-hydroxy-8-aza-2,3-dioxabicyclo[4.4.0]decane-6-carboxylate.
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