Zinc and p53 disrupt mitochondrial binding of HK2 by phosphorylating VDAC1.
作者： Ya-Nan Xue , Bing-Bing Yu , Jiu-Ling Li , Rui Guo , Li-Chao Zhang
DOI: 10.1016/J.YEXCR.2018.12.002
关键词: Programmed cell death 、 Voltage-dependent anion channel 、 Protein kinase B 、 Cancer 、 Biology 、 Cell biology 、 VDAC1 、 Apoptosis 、 Prostate cancer 、 GSK-3
摘要: … in both prostate cancer patient tissue and prostate cancer cell … in prostate cancer cells by phosphorylating VDAC1, which is … significantly inhibited tumor growth in a prostate cancer cell …
sci-hub.se 参考文章(46)
Saroj P. Mathupala, Annette Rempel, Peter L. Pedersen, Aberrant glycolytic metabolism of cancer cells: A remarkable coordination of genetic, transcriptional, post-translational, and mutational events that lead to a critical role for Type II hexokinase Journal of Bioenergetics and Biomembranes. ,vol. 29, pp. 339- 343 ,(1997) , 10.1023/A:1022494613613
Ba X. Hoang, Bo Han, David Graeme Shaw, Marcel Nimni, Zinc as a possible preventive and therapeutic agent in pancreatic, prostate, and breast cancer. European Journal of Cancer Prevention. ,vol. 25, pp. 457- 461 ,(2016) , 10.1097/CEJ.0000000000000194
Katarzyna B. Leszczynska, Iosifina P. Foskolou, Aswin G. Abraham, Selvakumar Anbalagan, Céline Tellier, Syed Haider, Paul N. Span, Eric E. O’Neill, Francesca M. Buffa, Ester M. Hammond, Hypoxia-induced p53 modulates both apoptosis and radiosensitivity via AKT Journal of Clinical Investigation. ,vol. 125, pp. 2385- 2398 ,(2015) , 10.1172/JCI80402
Nurmaa Dashzeveg, Kiyotsugu Yoshida, Cell death decision by p53 via control of the mitochondrial membrane Cancer Letters. ,vol. 367, pp. 108- 112 ,(2015) , 10.1016/J.CANLET.2015.07.019
Zhong Yun, Peter M. Glazer, Tumor suppressor p53 stole the AKT in hypoxia Journal of Clinical Investigation. ,vol. 125, pp. 2264- 2266 ,(2015) , 10.1172/JCI82058
Valerie P Tan, Shigeki Miyamoto, HK2/hexokinase-II integrates glycolysis and autophagy to confer cellular protection. Autophagy. ,vol. 11, pp. 963- 964 ,(2015) , 10.1080/15548627.2015.1042195
Guiditta Viticchiè, Massimiliano Agostini, Anna Maria Lena, Mara Mancini, Huiqing Zhou, Lello Zolla, David Dinsdale, Gaelle Saintigny, Gerry Melino, Eleonora Candi, p63 supports aerobic respiration through hexokinase II Proceedings of the National Academy of Sciences of the United States of America. ,vol. 112, pp. 11577- 11582 ,(2015) , 10.1073/PNAS.1508871112
Hilal Kocdor, Halil Ates, Suleyman Aydin, Ruksan Cehreli, Firat Soyarat, Pinar Kemanli, Duygu Harmanci, Hakan Cengiz, Mehmet Kocdor, Zinc supplementation induces apoptosis and enhances antitumor efficacy of docetaxel in non-small-cell lung cancer. Drug Design Development and Therapy. ,vol. 9, pp. 3899- 3909 ,(2015) , 10.2147/DDDT.S87662
Andrew P Halestrap, Gonçalo C Pereira, Philippe Pasdois, None, The role of hexokinase in cardioprotection – mechanism and potential for translation British Journal of Pharmacology. ,vol. 172, pp. 2085- 2100 ,(2015) , 10.1111/BPH.12899
Patrizia De Sarno, Xiaohua Li, Richard S. Jope, Regulation of Akt and glycogen synthase kinase-3β phosphorylation by sodium valproate and lithium Neuropharmacology. ,vol. 43, pp. 1158- 1164 ,(2002) , 10.1016/S0028-3908(02)00215-0