Methods of treating Prader-Willi syndrome

作者: Rudolph L. Leibel , Lisa Cole Burnett , Dieter Egli , Sara Cotter

DOI:

关键词: Prohormone convertaseInternal medicineMedicineEndocrinology

摘要: The present invention relates to methods for regulating prohormone convertase (PC1 ) and compounds treatments which increase PC1 levels, treating Prader-Willi Syndrome (PWS).

参考文章(47)
Takeshi Onda, Yoko Hashimoto, Masashi Nagai, Hiroshi Kuramochi, Seiichi Saito, Hiroko Yamazaki, Yoshiyuki Toya, Ikuko Sakai, Charles J. Homcy, Kiyohiro Nishikawa, Yoshihiro Ishikawa, Type-specific Regulation of Adenylyl Cyclase SELECTIVE PHARMACOLOGICAL STIMULATION AND INHIBITION OF ADENYLYL CYCLASE ISOFORMS Journal of Biological Chemistry. ,vol. 276, pp. 47785- 47793 ,(2001) , 10.1074/JBC.M107233200
Pinar Gumus Balikcioglu, Metin Balikcioglu, Michael J. Muehlbauer, Jonathan Q. Purnell, David Broadhurst, Michael Freemark, Andrea M. Haqq, Macronutrient Regulation of Ghrelin and Peptide YY in Pediatric Obesity and Prader-Willi Syndrome. The Journal of Clinical Endocrinology and Metabolism. ,vol. 100, pp. 3822- 3831 ,(2015) , 10.1210/JC.2015-2503
Dali Chen, Abhimanyu Garg, Monogenic disorders of obesity and body fat distribution Journal of Lipid Research. ,vol. 40, pp. 1735- 1746 ,(1999) , 10.1016/S0022-2275(20)34890-2
Robert S. Jackson, John W.M. Creemers, Shinya Ohagi, Marie-Laure Raffin-Sanson, Louise Sanders, Carl T. Montague, John C. Hutton, Stephen O'Rahilly, Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene Nature Genetics. ,vol. 16, pp. 303- 306 ,(1997) , 10.1038/NG0797-303
Esteban O Mazzoni, Shaun Mahony, Michael Closser, Carolyn A Morrison, Stephane Nedelec, Damian J Williams, Disi An, David K Gifford, Hynek Wichterle, Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity Nature Neuroscience. ,vol. 16, pp. 1219- 1227 ,(2013) , 10.1038/NN.3467
Evan S Deneris, Oliver Hobert, Maintenance of postmitotic neuronal cell identity Nature Neuroscience. ,vol. 17, pp. 899- 907 ,(2014) , 10.1038/NN.3731
Sandra Blaess, Nora Szabó, Roberta Haddad-Tóvolli, Xunlei Zhou, Gonzalo Álvarez-Bolado, Sonic hedgehog signaling in the development of the mouse hypothalamus Frontiers in Neuroanatomy. ,vol. 8, pp. 156- 156 ,(2015) , 10.3389/FNANA.2014.00156