Engineering gene expression and protein synthesis by modulation of nuclear shape

作者: C. H. Thomas , J. H. Collier , C. S. Sfeir , K. E. Healy

DOI: 10.1073/PNAS.032668799

关键词: Cell biologyCellular differentiationNuclear matrixProtein biosynthesisNucleusCytoskeletonTranscription factorGene expressionMolecular biologyCell nucleusBiology

摘要: … , and gene expression is in its infancy. Here we introduce a method for investigating gene-… Gene expression and protein synthesis were altered by changing nuclear shape. Collagen I …

参考文章(26)
Ronald Berezney, Michael J. Mortillaro, Hong Ma, Xiangyun Wei, Jagath Samarabandu, The Nuclear Matrix: A Structural Milieu for Genomic Function International Review of Cytology. ,vol. 162, pp. 1- 65 ,(1996) , 10.1016/S0074-7696(08)61228-0
E. Ruoslahti, Cell Biology: Enhanced: Stretching Is Good for a Cell Science. ,vol. 276, pp. 1345- 1346 ,(1997) , 10.1126/SCIENCE.276.5317.1345
D Kleinfeld, KH Kahler, PE Hockberger, Controlled outgrowth of dissociated neurons on patterned substrates The Journal of Neuroscience. ,vol. 8, pp. 4098- 4120 ,(1988) , 10.1523/JNEUROSCI.08-11-04098.1988
J. P. Bidwell, A. J. Van Wijnen, E. G. Fey, S. Dworetzky, S. Penman, J. L. Stein, J. B. Lian, G. S. Stein, Osteocalcin gene promoter-binding factors are tissue-specific nuclear matrix components. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 90, pp. 3162- 3166 ,(1993) , 10.1073/PNAS.90.8.3162
R Singhvi, A Kumar, G. Lopez, G. Stephanopoulos, D. Wang, G. Whitesides, D. Ingber, Engineering Cell Shape and Function. Science. ,vol. 264, pp. 696- 698 ,(1994) , 10.1126/SCIENCE.8171320
Carson H. Thomas, Clive D. McFarland, Michelle L. Jenkins, Alireza Rezania, Jack G. Steele, Kevin E. Healy, The role of vitronectin in the attachment and spatial distribution of bone-derived cells on materials with patterned surface chemistry Journal of Biomedical Materials Research. ,vol. 37, pp. 81- 93 ,(1997) , 10.1002/(SICI)1097-4636(199710)37:1<81::AID-JBM10>3.0.CO;2-T
Scott C. Wittelsberger, Kenneth Kleene, Sheldon Penman, Progressive loss of shape-responsive metabolic controls in cells with increasingly transformed phenotype Cell. ,vol. 24, pp. 859- 866 ,(1981) , 10.1016/0092-8674(81)90111-2
C. H. Thomas, J.-B. Lhoest, D. G. Castner, C. D. McFarland, K. E. Healy, Surfaces designed to control the projected area and shape of individual cells. Journal of Biomechanical Engineering-transactions of The Asme. ,vol. 121, pp. 40- 48 ,(1999) , 10.1115/1.2798041
Y. Wada, H. Kataoka, S. Yokose, T. Ishizuya, K. Miyazono, Y.-H. Gao, Y. Shibasaki, A. Yamaguchi, Changes in osteoblast phenotype during differentiation of enzymatically isolated rat calvaria cells Bone. ,vol. 22, pp. 479- 485 ,(1998) , 10.1016/S8756-3282(98)00039-8