Regulation of ornithine decarboxylase synthesis effect of a nutritional deficiency of vitamin B6

作者: John A. Sturman , Leon T. Kremzner

DOI: 10.1016/0024-3205(74)90087-3

关键词: Ornithine decarboxylaseEnzymePutrescineBiochemistryNutritional deficiencyPyridoxal phosphateChemistryOrnithine decarboxylase antizymeVitamin b6Spermidine

摘要: Abstract In vitamin B 6 deficiency there is an increase in the activity of pyridoxal phosphate dependent enzyme ornithine decarboxylase. rat liver: apoenzyme and holoenzyme increased 1.6 4 fold respectively. Concomitantly, putrescine spermidine concentrations were halved. The lack correspondence between product concentration enzymic suggests a control mechanism other than decarboxylase activity.

参考文章(28)
Diane H. Russell, Thomas A. McVicker, Polyamine biogenesis in the rat mammary gland during pregnancy and lactation. Biochemical Journal. ,vol. 130, pp. 71- 76 ,(1972) , 10.1042/BJ1300071
A E Pegg, H G Williams-Ashman, On the Role of S-Adenosyl-l-methionine in the Biosynthesis of Spermidine by Rat Prostate Journal of Biological Chemistry. ,vol. 244, pp. 682- 693 ,(1969) , 10.1016/S0021-9258(18)94408-X
James D. Finkelstein, Frances T. Chalmers, Pyridoxine Effects on Cystathionine Synthase in Rat Liver The Journal of Nutrition. ,vol. 100, pp. 467- 469 ,(1970) , 10.1093/JN/100.4.467
George Weber, H. Guy Williams-Ashman, Gordon L. Coppoc, Imbalance in ornithine metabolism in hepatomas of different growth rates as expressed in formation of putrescine, spermidine, and spermine. Cancer Research. ,vol. 32, pp. 1924- 1932 ,(1972)
J. Jänne, H.G. Williams-Ashman, With the technical assistance of Mary E. Geroch, On the Purification of l-Ornithine Decarboxylase from Rat Prostate and Effects of Thiol Compounds on the Enzyme Journal of Biological Chemistry. ,vol. 246, pp. 1725- 1732 ,(1971) , 10.1016/S0021-9258(18)62370-1
A. Lewis Farr, Oliver H. Lowry, Rose J. Randall, Nira J. Rosebrough, Protein Measurement with the Folin Phenol Reagent Journal of Biological Chemistry. ,vol. 193, pp. 265- 275 ,(1951)
Anthony C. Trakatellis, A. E. Axelrod, EFFECT OF PYRIDOXINE DEFICIENCY UPON VALINE INCORPORATION INTO TISSUE PROTEINS OF THE RAT. Journal of Nutrition. ,vol. 82, pp. 483- 488 ,(1964) , 10.1093/JN/82.4.483
Wan-Hee Y. Moon, Avanelle Kirksey, Cellular Growth during Prenatal and Early Postnatal Periods in Progeny of Pyridoxine-deficient Rats The Journal of Nutrition. ,vol. 103, pp. 123- 133 ,(1973) , 10.1093/JN/103.1.123
Marvin J. Feldman, Carl C. Levy, Diane H. Russell, The purification of S-adenosyl-l-methionine decarboxylase from rat liver: Inability to separate decarboxylation from spermidine synthesis Biochemical and Biophysical Research Communications. ,vol. 44, pp. 675- 681 ,(1971) , 10.1016/S0006-291X(71)80136-5
YAO C. G. DZODZŒ, ELSA ROSENGREN, Decarboxylases of histidine and ornithine in chick embryo. British Journal of Pharmacology. ,vol. 41, pp. 294- 301 ,(1971) , 10.1111/J.1476-5381.1971.TB08030.X