Chronic oral infection: An emerging risk factor of cerebral small vessel disease

摘要: Chronic oral infections (gingivitis/periodontitis) have been associated with age-related diseases such as diabetes, coronary heart disease, and acute ischemic stroke. In addition, imaging surrogates of cerebrovascular ischemia beyond stroke (i.e., silent strokes brain white matter hyperintensities) may also be chronic infections. The pathology underlying lacunar hyperintensities (WMH) relates to small vessel disease in the brain. this review, we highlight recent progress exploring potential associations cerebral its (silent strokes, clinical sequelae vascular dementia). Recent evidence suggests that periodontitis aggravates increases risk. Moreover, interacts Alzheimer's increase severity dementia accelerate manifestations. results suggest an emerging risk factor disease-associated disorders mediated by systemic inflammation resulting from Large cohort studies employing state-of-the-art magnetic resonance techniques identify specific pathologies a function time, health status, are needed further substantiate hypothesis.