Recent advances in understanding the ryanodine receptor calcium release channels and their role in calcium signalling.

摘要: The ryanodine receptor calcium release channel is central to cytoplasmic Ca 2+ signalling in skeletal muscle, the heart, and many other tissues, including nervous system, lymphocytes, stomach, kidney, adrenal glands, ovaries, testes, thymus, lungs. ion protein massive (more than 2.2 MDa) has a structure that defied detailed determination until recent developments cryo-electron microscopy revealed much of its at near-atomic resolution. availability this high-resolution provided most significant advances understanding function past 30 years. We can now visualise molecular environment individual amino acid residues form binding sites for essential modulators determine role signalling. Importantly, structural deletions point mutations disrupt cardiac myopathies neuropathies. implications are vital importance our basis channel’s design therapies counteract effects receptor-associated disorders.