Substrate specificity of Fpg protein. Recognition and cleavage of oxidatively damaged DNA.

作者: J Tchou , S Shibutani , F Johnson , A P Grollman , I Antoshechkin

DOI: 10.1016/S0021-9258(17)36608-5

关键词: Specificity constantGuanineChemistryStereochemistryDNA-(apurinic or apyrimidinic site) lyaseDNA damageDNA-formamidopyrimidine glycosylaseFormamidopyrimidine DNA glycosylaseDNA glycosylaseBiochemistryEnzyme kinetics

摘要: … Fpg protein and to establish the role of functional groups in DNA on damage recognition and catalysis. Binding affinities of Fpg … of formamidopyrimidine enable Fpg protein to recognize …

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