Synthetic hydrogels as drug delivery systems
作者： W. E. Roorda , H. E. BoddÉ , A. G. de Boer , H. E. Junginger
DOI: 10.1007/BF01959775
关键词: Drug delivery 、 Sustained release drug 、 Polymer 、 Biocompatible material 、 Biocompatibility 、 Self-healing hydrogels 、 Materials science 、 Dosage form 、 Nanotechnology
摘要: Hydrogels are widely studied materials for the preparation of sustained release drug dosage forms. Their soft, tissue-like consistency and their high biocompatibility in a number applications make them promising candidates this purpose. The water polymer gel form intricate structures much research has been devoted to elucidation these structures, interactions involved formation. Simple, drug-loaded hydrogels normally give matrix-type delivery profile, which rate is proportional square root time; approaches used change profile other types delivery, instance zero-order release. A ofin vivo tests using hydrogel systems given favourable results.
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