Chemical constituents and leishmanicidal activity from leaves of Kielmeyera variabilis
作者： Betania B. Cota , Ezequias P. Siqueira , Djalma M. de Oliveira , Tânia M. A. Alves , Marcos E. G. Sobral
DOI: 10.1590/S0102-695X2012005000095
关键词: Isovitexin 、 Botany 、 Kielmeyera 、 Kaempferol 、 Quercetin 、 Traditional medicine 、 Quercitrin 、 Calophyllum 、 Calophyllaceae 、 Biology 、 Triterpene
摘要: Many phenolic compounds such as xanthones, quinones and coumarins have been isolated from Kielmeyera species; however the presence of flavonoids showed in other genera Calophylleae tribe Caraipa, Mesua Calophyllum. Six known glycosidic flavonoids: quercetin 3-β-O-galactopyranoside (1), 3-β-O-glucopyranoside (2), 3-O-α-rhamnoside (3), luteolin 6-C-β-glucopyranoside (4), isovitexin (5), kaempferol (6) one triterpene, lupenone (7) were isolated, for first time, organic crude extract variabilis Mart. & Zucc., Calophyllaceae, leaves. The K. leaves exhibited 95% leishmanidal activity at 20 µg/mL on amastigote-like form Leishmania (Leishmania) amazonensis vitro model only compound 3 40-45% growth inhibition concentration ranging 0.78 to µg/mL. In addition, (quercitrin) was found be major metabolite. Our results previous reports suggest that synergistic effects flavonoid glycosides are cause significant
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