Scintigraphic assessment of salivary function and excretion response in radiation-induced injury of the major salivary glands.

摘要: Background. Both loss of the secretory function and impairment excretion may play a role in radiationinduced injury major salivary glands after radiotherapy for head neck malignancies. Therefore, quantitative 99mTc-pertechnetate (99mTc) scintigraphy to assess trapping, secretion, excretion, was used analyze irradiation-induced changes relation radiation dose time interval radiotherapy. Patients Methods. Salivary performed on 25 patients who had been irradiated various malignancies with irradiation 6 nonirradiated patients. Excretion induced by stimulation carbachol (Carbacholum, Pharmachemie BV, Haarlem, The Netherlands). As parameter glandular trapping cumulative uptake first 12 minutes used. Scintigraphic data were analyzed each patient individual gland at three levels (range, 5–70 Gy), short 2–7 months) long 10–50 intervals radiotherapy. Results. response stimulant totally or partially disturbed 84% For glands, maintained all Gy less, nearly half doses 25–45 Gy, almost invariably impaired higher than 45 regardless radiotherapy. Although 99mTc tended decrease (z = −3.059, P ≤ 0.0022), more, considerably examined postirradiation compared (P 0.0001). This tendency, seen both parotid submandibular not observed lower Gy. Conclusion. These suggest that period high irradiation, xerostomia is based predominantly failure excrete saliva, whereas later period, decreased ability together an additional role. using suitable method radiation-induced injury. test able detect dysfunction early phase be useful predict which will respond symptomatically stimulants. Cancer 1994; 73:2886–93.