Tailor-Made Temperature-Sensitive Micelle for Targeted and On-Demand Release of Anticancer Drugs.
作者： S. Panja , G. Dey , R. Bharti , K. Kumari , T. K. Maiti
关键词: Lower critical solution temperature 、 Critical micelle concentration 、 Polymer 、 Chemical engineering 、 Copolymer 、 Drug carrier 、 Pentaerythritol 、 Micelle 、 Materials science 、 Nanotechnology 、 Drug delivery
摘要: The design of nanomedicines from the tuned architecture polymer is a leading object immense research in recent years. Here, smart thermoresponsive micelles were prepared novel four-arm star block copolymers, namely, pentaerythritol polycaprolactone-b-poly(N-isopropylacrylamide) and polycaprolactone-b-poly(N-vinylcaprolactam). polymers synthesized tagged with folic acid (FA) to render them as efficient cancer cell targeting cargos. FA-conjugated copolymers self-assembled nearly spherical (ranging 15 170 nm) polymeric micelle (FA-PM) sufficiently lower range critical concentration (0.59 × 10–2 1.52 mg/mL) suitable for performing an drug carrier. blocks show solution temperature (LCST) ranging 30 39 °C high DOX-loading content (24.3%, w/w) compared that reported linear contemporary literature. temperature-induced reduction size (5...
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