Le ganglion sentinelle post chimiothérapie

作者: Pierre Gimbergues

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摘要: Une desescalade therapeutique des traitements du cancer sein est observee notamment grâce a la chimiotherapie neo-adjuvante (CNA). Alors que technique ganglion sentinelle (GS) n'est actuellement pas recommandee apres CNA, nous avons demontre sa faisabilite dans une serie prospective de 129 patientes traitees par CNA avec un taux d'identification 93,8%, FN 14,3% et 0% pour les N0 avant CNA. En cas d'atteinte duGS, le risque GNS metastatique etait correle taille tumorale (p=0.016) metastase GS (p=0.0055). Le nomogramme MD Anderson (AUC=0.716) score Thenon (AUC=0.778) pouvaient evaluer probabilite GNS. L'analyse per operatoire apposition permis l'identification d'une chez 72% (sensibilite=38.2% ; specificite=97.8%). Les qui presentaient micro ou presence cellules tumorales isolees avaient multiplie 2,3 l'apposition rapport aux atteinte macro metastatique. conclusion, notre travail montrer n'avait d'influence negative sur GS, en particulier clinique traitement. Apres l'analyse possible ainsi l'utilisation certains nomogrammes deja existants calculer lorsque

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