Catalpol suppressed proliferation, growth and invasion of CT26 colon cancer by inhibiting inflammation and tumor angiogenesis.

摘要: Tumor angiogenesis and inflammation, which play important roles in mediating tumor proliferation growth, should be inhibited to effectively regulate progression. Catalpol, a main active ingredient extracted from Rehmannia glutinosa, has various pharmacological actions including anti-apoptotic, anti-inflammatory, hypoglycemic anti-cancer properties. However, the effect of catalpol on colon cancer remains largely unknown. The aim this study was investigate effects proliferation, invasion, inflammation CT26 vitro vivo. Catalpol growth cells concentration- dose-dependent manners vivo, respectively. suppressed invasion vitro. cell-induced vascularization endothelial rat aortic ring were impaired by catalpol. reduced secretions several angiogenic markers culture supernatant cells. Immunohistochemical assay showed that expressions vascular factor (VEGF), receptor 2 (VEGFR2), hypoxia inducible factor-1α (HIF-1α) basic fibroblast (bFGF) tissues. Moreover, inflammatory factors interleukin-1β (IL-1β), IL-6, IL-8, cyclooxygenase (COX-2) nitric oxide synthase (iNOS). Taken together, mainly inhibiting angiogenesis, as promising candidate compound for treating cancer.