A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals.

摘要: We conducted a case-control genome-wide association study (GWAS) of human longevity, comparing 664,472 autosomal SNPs in 763 long-lived individuals (LLI; mean age: 99.7 years) and 1085 controls (mean 60.2 from Germany. Only one association, namely that SNP rs4420638 near the APOC1 gene, achieved significance (allele-based P = 1.8 x 10(-10)). However, logistic regression analysis revealed this which was replicated an independent German sample, is fully explicable by linkage disequilibrium with APOE allele epsilon 4, only variant hitherto established as major genetic determinant survival into old age. Our GWAS failed to identify any additional susceptibility genes. One explanation for lack success our would be provide limited statistical power polygenic phenotype loci small effect such longevity. A recent Dutch LLI independently confirmed APOE-longevity thus strengthening conclusion locus very, if not most, important factor influencing (C) 2011 Elsevier Ireland Ltd. All rights reserved.