Steps towards a repertoire of comprehensive maps of human protein interaction networks: the Human Proteotheque Initiative (HuPI).

摘要: Defining human protein interaction networks has become essential to develop an overall, systems-based understanding of the molecular events that sustain cell growth in normal and disease conditions. To characterize from cells, we have undertaken development a systematic, unbiased technology pipeline couples experimental computational approaches. This discovery engine is central Human Proteotheque Initiative (HuPI), multidisciplinary project aimed at building repertoire comprehensive maps networks, Proteotheque. The information contained made publicly available through interactive web site can be consulted visualize some fundamental connections formed cells determine putative functions previously uncharacterized proteins based on guilt by association. process governing evolution HuPI towards becoming repository accurate complete described.