Recurrent IVF failure and hereditary thrombophilia.
作者： Leila Safdarian , Mandana Rashidi , Ashraf Aleyasin , Zahra Najmi , Sara Asadollah
DOI:
关键词: Risk factor 、 Antithrombin 、 Mutation (genetic algorithm) 、 Factor V Leiden 、 Medicine 、 Protein S 、 Gynecology 、 Thrombophilia 、 Methylenetetrahydrofolate reductase 、 Fertility
摘要: Background: Objective: Aim of this case-control study was to determine whether hereditary thrombophilia is more prevalent in women with recurrent IVF failures. Materials and Methods: Case group comprised 96 infertile women, a history failure. Control 95 healthy proven fertility who had conceived spontaneously. All participants were assessed for the presence inherited thrombophilias including: factor V Leiden, methilen tetrahydrofolate reductase (MTHFR) mutation, prothrombin homocystein level, protein S C deficiency, antithrombin III (AT-III) deficiency plasminogen activator inhibitor-1 (PAI-1) mutation. Presence compared between groups. Results: Having at least one known as risk failure (95% CI=1.74-5.70, OR=3.15, p=0.00). Mutation Leiden CI=1.26-10.27, OR=3.06, P=0.01) homozygote form MTHFR mutation CI=1.55-97.86, OR=12.33, p=0.05) also factors However, we could not find significant difference other thrombophilia’s. Conclusion: Inherited women. thrombophilia, failur e. The largest percentage failed invitro fertilization (IVF) cycles, are due lack implantation. As can cause placentation failure, it may have role
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