Enhancers and their dynamics during hematopoietic differentiation and emerging strategies for therapeutic action.
作者： Alba Cico , Charlotte Andrieu-Soler , Eric Soler
关键词: Context (language use) 、 Haematopoiesis 、 Cellular differentiation 、 Gene expression 、 Function (biology) 、 Genome 、 Transcription factor 、 Computational biology 、 Enhancer 、 Biology
摘要: Cellular differentiation requires precisely regulated tissue-specific and developmental stage-specific gene expression patterns. Numerous studies have highlighted the predictive power of enhancers on lineage-specific programs started to unravel their mechanisms action. We review here dynamics enhancer landscape during hematopoietic how function in context 3D organization genome. further discuss involvement aberrant activity human diseases emerging strategies aiming at controlling chromosome topology for therapeutic purposes.
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