Hot Food and Beverage Consumption and the Risk of Esophageal Cancer: A Meta-Analysis

摘要: Context Esophageal cancer is a neoplasm with poor prognosis. Its two histologic subtypes, esophageal squamous cell carcinoma (ESCC) and adenocarcinoma (EAC), have been associated different risk factors. The possibility of an association between the consumption hot food beverages cancer, especially ESCC, has long suspected, presenting potentially modifiable factor. A meta-analysis existing observational studies was performed to provide quantitative estimate drink. Evidence acquisition search conducted through MEDLINE, PubMed, EMBASE, Current Contents Connect November 11, 2014. Pooled ORs 95% CIs were calculated using random effects model for Subgroup analyses ESCC EAC, as well that adjusted tobacco smoking alcohol consumption, well-recognized factors ESCC. synthesis Consumption drink increased any (OR=1.90, CI=1.46, 2.48). Heterogeneity observed. There (OR=2.29, CI=1.79, 2.93), which remained even after adjusting significant confounding variables (OR=2.39, CI=1.71, 3.33). relationship not EAC. Conclusions particularly