Effect of recent spinal cord injury on wnt signaling antagonists (sclerostin and dkk-1) and their relationship with bone loss. A 12-month prospective study.
作者： Laia Gifre , Joan Vidal , Josep L Carrasco , Xavier Filella , Silvia Ruiz-Gaspà
DOI: 10.1002/JBMR.2423
关键词: Pathogenesis 、 Osteoporosis 、 Bone remodeling 、 Bone mineral 、 Internal medicine 、 Spinal cord injury 、 Endocrinology 、 Medicine 、 Osteocyte 、 Wnt signaling pathway 、 Sclerostin
摘要: Spinal cord injury (SCI) has been associated with a marked increase in bone loss and remodeling, especially short-term after injury. The absence of mechanical load, mediated by osteocyte mechanosensory function, seems to be causative factor related this condition. However, the pathogenesis clinical management process remain unclear. Therefore, aim study was analyze effect recent SCI on Wnt pathway antagonists, sclerostin Dickkopf (Dkk-1), their relationship turnover mineral density (BMD) evolution. Forty-two patients (aged 35 ± 14yrs) ( 58 pmol/L) at baseline showed higher sublesional BMD loss. In conclusion, shows that there is loss, latter an Dkk-1 serum levels. persistence increased levels antagonist throughout magnitude suggests contributory role mediator process. © 2014 American Society for Bone Mineral Research.
sci-hub.se 参考文章(45)
Douglas Garland, Rodney Adkins, Charles Stewart, Five-Year Longitudinal Bone Evaluations In Individuals With Chronic Complete Spinal Cord Injury Journal of Spinal Cord Medicine. ,vol. 31, pp. 543- 550 ,(2008) , 10.1080/10790268.2008.11753650
Lora Giangregorio, Neil McCartney, Bone loss and muscle atrophy in spinal cord injury: epidemiology, fracture prediction, and rehabilitation strategies. Journal of Spinal Cord Medicine. ,vol. 29, pp. 489- 500 ,(2006) , 10.1080/10790268.2006.11753898
Alyson Morse, Michelle Maree McDonald, Natalie H Kelly, Katherine M Melville, Aaron Schindeler, Ina Kramer, Michaela Kneissel, Marjolein CH van der Meulen, David Graham Little, Mechanical Load Increases in Bone Formation via a Sclerostin‐Independent Pathway Journal of Bone and Mineral Research. ,vol. 29, pp. 2456- 2467 ,(2014) , 10.1002/JBMR.2278
William P. Waring, Fin Biering-Sorensen, Stephen Burns, William Donovan, Daniel Graves, Amitabh Jha, Linda Jones, Steven Kirshblum, Ralph Marino, M. J. Mulcahey, Ronald Reeves, William M. Scelza, Mary Schmidt-Read, Adam Stein, 2009 Review and Revisions of the International Standards for the Neurological Classification of Spinal Cord Injury Journal of Spinal Cord Medicine. ,vol. 33, pp. 346- 352 ,(2010) , 10.1080/10790268.2010.11689712
Martin Kaiser, Maren Mieth, Peter Liebisch, Romy Oberländer, Jessica Rademacher, Christian Jakob, Lorenz Kleeberg, Claudia Fleissner, Edgar Braendle, Malte Peters, David Stover, Orhan Sezer, Ulrike Heider, Serum concentrations of DKK‐1 correlate with the extent of bone disease in patients with multiple myeloma European Journal of Haematology. ,vol. 80, pp. 490- 494 ,(2008) , 10.1111/J.1600-0609.2008.01065.X
M Elmelund, P S Oturai, F Biering-Sørensen, 50 years follow-up on plasma creatinine levels after spinal cord injury Spinal Cord. ,vol. 52, pp. 368- 372 ,(2014) , 10.1038/SC.2014.24
David Roberts, Winnifred Lee, Ross C. Cuneo, Johannes Wittmann, Greg Ward, Robert Flatman, Brett McWhinney, Peter E. Hickman, Longitudinal study of bone turnover after acute spinal cord injury. The Journal of Clinical Endocrinology and Metabolism. ,vol. 83, pp. 415- 422 ,(1998) , 10.1210/JCEM.83.2.4581
Ricardo A. Battaglino, Supreetha Sudhakar, Antonio A. Lazzari, Eric Garshick, Ross Zafonte, Leslie R. Morse, Circulating sclerostin is elevated in short-term and reduced in long-term SCI☆ Bone. ,vol. 51, pp. 600- 605 ,(2012) , 10.1016/J.BONE.2012.04.019
Alexander G. Robling, Paul J. Niziolek, Lee A. Baldridge, Keith W. Condon, Matthew R. Allen, Imranul Alam, Sara M. Mantila, Jelica Gluhak-Heinrich, Teresita M. Bellido, Stephen E. Harris, Charles H. Turner, Mechanical stimulation of bone in vivo reduces osteocyte expression of Sost/sclerostin Journal of Biological Chemistry. ,vol. 283, pp. 5866- 5875 ,(2008) , 10.1074/JBC.M705092200
Oran D. Kennedy, Brad C. Herman, Damien M. Laudier, Robert J. Majeska, Hui B. Sun, Mitchell B. Schaffler, Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations. Bone. ,vol. 50, pp. 1115- 1122 ,(2012) , 10.1016/J.BONE.2012.01.025