Antioxidant and genotoxic properties of South African herbal extracts

摘要: This study investigated the antioxidant and genotoxic properties of 13 South African herbal extracts. Results from singlecell gel electrophoresis (Comet) assay indicated that there were profound differences between plant extracts in their ability to produce DNA damage, which varied highly protective. Similarly, water methanol all preparations showed variable potencies scavenging hydroxyl radicals, as measured by means electron spin resonance spectrometery (ESR) with trap-phenyl-N-tert-butylnitrone (PBN). In general, better scavengers radicals than corresponding was also true these inhibit membrane lipid peroxidation, assessed diphenyl-1-pyrenylphosphine (DPPP). However, neither nor had protect against damage. The results show further research on traditional is imperative gain understanding mechanisms involved pharmacological effects. tests implemented present investigation are recommended for screening other © 2004 Elsevier B.V. All rights reserved.