Ethics of HIV and hepatitis B cure research.
作者： Jeremy Sugarman
DOI: 10.1097/COH.0000000000000618
关键词: Hepatitis B 、 Variety (cybernetics) 、 Terminology 、 Hepatitis B virus 、 Normative 、 Scholarship 、 Human immunodeficiency virus (HIV) 、 Stigma (botany) 、 Nursing 、 Psychology
摘要: PURPOSE OF REVIEW Achieving a cure for HIV or hepatitis B virus (HBV) is expected to have range of salutary effects including eliminating the need continued treatments, minimizing risk sexual and injecting partners, reducing prevalence, decreasing stigma. Nevertheless, conducting research achieve such laudable goals necessarily associated with broad set ethical challenges. This review aims at describing key findings from selected peer-reviewed literature published in last 2 years (2018-2019) that enhance understanding some these issues. RECENT FINDINGS A variety issues been informed by recent conceptual empirical scholarship. These include: analytical treatment interruptions; attitudes towards participation; responsibilities nonparticipants; consent terminology; other SUMMARY Understanding has enhanced sustained normative scholarship stakeholders. work crucial implications HBV research, but there also pressing directed on research. In both promises help ensure critically important efforts are ethically sound.
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sci-hub.st 参考文章(26)
Jeremy Sugarman, HIV Cure Research: Expanding the Ethical Considerations Annals of Internal Medicine. ,vol. 159, pp. 490- 491 ,(2013) , 10.7326/0003-4819-159-7-201310010-00694
, Towards an HIV cure: a global scientific strategy Nature Reviews Immunology. ,vol. 12, pp. 607- 614 ,(2012) , 10.1038/NRI3262
Nir Eyal, Daniel R Kuritzkes, Challenges in clinical trial design for HIV-1 cure research. The Lancet. ,vol. 382, pp. 1464- 1465 ,(2013) , 10.1016/S0140-6736(13)62040-1
Bernard Lo, Christine Grady, Working Group on Ethics of the International AIDS Society, Ethical considerations in HIV cure research: points to consider. Current Opinion in Hiv and Aids. ,vol. 8, pp. 243- 249 ,(2013) , 10.1097/COH.0B013E32835EA1C5
Nir Eyal, The benefit/risk ratio challenge in clinical research, and the case of HIV cure: an introduction Journal of Medical Ethics. ,vol. 43, pp. 65- 66 ,(2017) , 10.1136/MEDETHICS-2016-103427
Steven G Deeks, Sharon R Lewin, Anna Laura Ross, Jintanat Ananworanich, Monsef Benkirane, Paula Cannon, Nicolas Chomont, Daniel Douek, Jeffrey D Lifson, Ying-Ru Lo, Daniel Kuritzkes, David Margolis, John Mellors, Deborah Persaud, Joseph D Tucker, Françoise Barre-Sinoussi, International AIDS Society Towards a Cure Working Group, Galit Alter, Judith Auerbach, Brigitte Autran, Dan H Barouch, Georg Behrens, Marina Cavazzana, Zhiwei Chen, Éric A Cohen, Giulio Maria Corbelli, Serge Eholié, Nir Eyal, Sarah Fidler, Laurindo Garcia, Cynthia Grossman, Gail Henderson, Timothy J Henrich, Richard Jefferys, Hans-Peter Kiem, Joseph McCune, Keymanthri Moodley, Peter A Newman, Monique Nijhuis, Moses Supercharger Nsubuga, Melanie Ott, Sarah Palmer, Douglas Richman, Asier Saez-Cirion, Matthew Sharp, Janet Siliciano, Guido Silvestri, Jerome Singh, Bruno Spire, Jeffrey Taylor, Martin Tolstrup, Susana Valente, Jan van Lunzen, Rochelle Walensky, Ira Wilson, Jerome Zack, None, International AIDS Society global scientific strategy: towards an HIV cure 2016 Nature Medicine. ,vol. 22, pp. 839- 850 ,(2016) , 10.1038/NM.4108
Jeremy Sugarman, Peter Revill, Fabien Zoulim, Yazdan Yazdanpanah, Harry L A Janssen, Seng Gee Lim, Sharon R Lewin, Ethics and hepatitis B cure research Gut. ,vol. 66, pp. 389- 392 ,(2017) , 10.1136/GUTJNL-2016-313009
Gail E Henderson, Holly L Peay, Eugene Kroon, Rosemary Jean Cadigan, Karen Meagher, Thidarat Jupimai, Adam Gilbertson, Jill Fisher, Nuchanart Q Ormsby, Nitiya Chomchey, Nittaya Phanuphak, Jintanat Ananworanich, Stuart Rennie, Ethics of treatment interruption trials in HIV cure research: addressing the conundrum of risk/benefit assessment Journal of Medical Ethics. ,vol. 44, pp. 270- 276 ,(2017) , 10.1136/MEDETHICS-2017-104433
Karine Dubé, Laurie Sylla, Lynda Dee, Jeff Taylor, David Evans, Carl Dean Bruton, Adam Gilberston, Lisa Gralinski, Brandon Brown, Asheley Skinner, Bryan J. Weiner, Sandra B. Greene, Amy Corneli, Adaora A. Adimora, Joseph D. Tucker, Stuart Rennie, Research on HIV cure: Mapping the ethics landscape. PLOS Medicine. ,vol. 14, ,(2017) , 10.1371/JOURNAL.PMED.1002470
Karine Dubé, Stuart Luter, Breanne Lesnar, Luke Newton, Jerome Galea, Brandon Brown, Sara Gianella, Use of 'Eradication' in HIV Cure-Related Research: a Public Health Debate BMC Public Health. ,vol. 18, pp. 245- 245 ,(2018) , 10.1186/S12889-018-5141-2