Ten-Year Follow-up of Age-Related Macular Degeneration in the Age-Related Eye Disease Study

摘要: Importance Providing long-term follow-up of the natural history age-related macular degeneration (AMD) and associated risk factors will facilitate future epidemiologic studies clinical trials. Objective To describe 10-year progression rates to intermediate or advanced AMD. Design, Setting, Participants We observed Age-Related Eye Disease Study (AREDS) participants for an additional 5 years after a randomized trial antioxidant vitamins minerals was completed. Observation occurred at 11 sites medical retinal practices from academic institutions community centers. aged 55 80 with no AMD varying severity (n = 4757) were followed up in AREDS median duration 6.5 years. When ended, 3549 4203 surviving Exposure Treatment minerals. Main Outcomes Measures Development stages changes visual acuity. The large drusen (neovascular central geographic atrophy) evaluated using annual fundus photographs assessed centrally. Best-corrected acuity measured study visits. Results increased increasing age ( P  = .01) drusen. Women  = .005) current smokers Conclusions Relevance demonstrates relentless loss vision persons who developed These data factor analyses may be helpful investigators conducting research clinic populations.