Theiler's Virus-Induced Demyelinating Disease

作者: Stephen D. Miller , William J. Karpus , Jonathan G. Pope , Mauro C. Dal Canto , Roger W. Melvold

DOI: 10.1016/B978-0-08-091736-8.50007-6

关键词: VirulenceVirusCapsidPicornaviridaeVirologyEncephalitisCardiovirusParalysisDemyelinating diseaseBiology

摘要: Publisher Summary This chapter focuses on Theiler's virus-induced demyelinating disease. murine encephalomyelitis viruses (TMEV) are members of the cardiovirus group Picornaviridae, and is composed three capsid proteins—VP1, VP2, VP3—that surround a single-stranded, plus-sense RNA genome associated with fourth structural protein, VP4. There two subgroups TMEV. One includes GD VII FA viruses, which grow to high titers, highly virulent, induce fatal encephalitis. The second group, known as original (TO) subgroup, Daniels BeAn 8386 strains that have low virulence, relatively produce persistent infection central nervous system (CNS) white matter extensive demyelination. A natural encounter TO initially leads enteric infections in mice, small percentage susceptible developing subsequent CNS, can lead chronic, progressive, disease characterized by spastic hind limb paralysis.

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