Regulation of phagocytosis by Rho GTPases.

摘要: Phagocytosis is defined as a cellular uptake pathway for particles of greater than 0.5 μm in diameter. Particle clearance by phagocytosis critical importance tissue health and homeostasis. The ultimate goal anti-pathogen to destroy engulfed bacteria or fungi stimulate cell-cell signaling that mount an efficient immune defense. In contrast, apoptotic cells cell debris anti-inflammatory. High capacity pathways are available professional phagocytes the system retina. Additionally, low capacity, so-called bystander phagocytic most other types. Different stimulated particle ligation distinct surface receptors but all forms require F-actin recruitment beneath tethered re-arrangement promoting engulfment, which controlled Rho family GTPases. specificity GTPase activity during differ...