Effects of physical exercise and social isolation on anxiety-related behaviors in two inbred rat strains.
作者： F.G. Mazur , L.F.G. Oliveira , M.P. Cunha , A.L.S. Rodrigues , R.A.N. Pértile
DOI: 10.1016/J.BEPROC.2017.06.001
关键词: Social isolation 、 Endocrinology 、 Treadmill 、 Medicine 、 Physical exercise 、 Locomotor activity 、 Open field 、 Anxiety 、 Male rats 、 Elevated plus maze 、 Internal medicine
摘要: We investigated the effects of physical exercise (PE) on locomotor activity and anxiety-like behavior in Lewis (LEW) Spontaneously Hypertensive Rats (SHR) male rats. received either four weeks forced training, 5 days/week, a treadmill (experiment 1) or were given 21 days free access to running wheels 2). also tested social isolation (SI) (seven − experiment 3) behavior. In 1, 20% LEW rats 63% SHR completed training protocol. PE significantly increased central peripheral locomotion open field (OF) entries into arms elevated plus-maze (EPM) both strains. 2, distance traveled by was higher compared with time spent center OF only. 3, SI decreased summary, reduced strains, whereas voluntary strains OF. This study suggests that spontaneous levels are genotype-dependent depend type performed.
uq.edu.au
core.ac.uk参考文章(75)
Hye Im Jeong, Eun-Sang Ji, Su-Hyun Kim, Tae-Wook Kim, Sang-Bin Baek, Seung Wook Choi, Treadmill exercise improves spatial learning ability by enhancing brain-derived neurotrophic factor expression in the attention-deficit/hyperactivity disorder rats. Journal of exercise rehabilitation. ,vol. 10, pp. 162- 167 ,(2014) , 10.12965/JER.140111
M.J. Skelly, A.E. Chappell, E. Carter, J.L. Weiner, Adolescent social isolation increases anxiety-like behavior and ethanol intake and impairs fear extinction in adulthood: Possible role of disrupted noradrenergic signaling Neuropharmacology. ,vol. 97, pp. 149- 159 ,(2015) , 10.1016/J.NEUROPHARM.2015.05.025
Patrícia Helena Zanier-Gomes, Tomaz Eugênio de Abreu Silva, Guilherme Cia Zanetti, Évelyn Raquel Benati, Nanci Mendes Pinheiro, Beatriz Martins Tavares Murta, Virgínia Oliveira Crema, Depressive behavior induced by social isolation of predisposed female rats Physiology & Behavior. ,vol. 151, pp. 292- 297 ,(2015) , 10.1016/J.PHYSBEH.2015.07.026
Karen J. Baumgartner, B. D. Roebuck, Jennifer McCaffrey, Protective Effects of Voluntary Exercise during the Postinitiation Phase of Pancreatic Carcinogenesis in the Rat Cancer Research. ,vol. 50, pp. 6811- 6816 ,(1990)
André Ramos, Edinéia C. Correia, Geison S. Izídio, Gustavo R. Brüske, Genetic selection of two new rat lines displaying different levels of anxiety-related behaviors. Behavior Genetics. ,vol. 33, pp. 657- 668 ,(2003) , 10.1023/A:1026131130686
Ilia J. Elenkov, Richard Kvetnansky, Akira Hashiramoto, Vladimir K. Bakalov, Amrey A. Link, Keith Zachman, Marianna Crane, Daniela Jezova, Jozef Rovensky, Mariana A. Dimitrov, Philip W. Gold, Sergio Bonini, Thomas Fleisher, George P. Chrousos, Ronald L. Wilder, Low- versus High-Baseline Epinephrine Output Shapes Opposite Innate Cytokine Profiles: Presence of Lewis- and Fischer-Like Neurohormonal Immune Phenotypes in Humans? Journal of Immunology. ,vol. 181, pp. 1737- 1745 ,(2008) , 10.4049/JIMMUNOL.181.3.1737
Zsolt Murlasits, A call for the better utilization of physical activity and exercise training in the defense against cardiovascular disease. The Physician and Sportsmedicine. ,vol. 43, pp. 329- 332 ,(2015) , 10.1080/00913847.2015.1095618
Jody Sharp, Toni Azar, David Lawson, Heart Rates of Male and Female Sprague–Dawley and Spontaneously Hypertensive Rats Housed Singly or in Groups Journal of The American Association for Laboratory Animal Science. ,vol. 50, pp. 175- 184 ,(2011)
Albert Moraska, Terrence Deak, Robert L. Spencer, David Roth, Monika Fleshner, Treadmill running produces both positive and negative physiological adaptations in Sprague-Dawley rats. American Journal of Physiology-regulatory Integrative and Comparative Physiology. ,vol. 279, ,(2000) , 10.1152/AJPREGU.2000.279.4.R1321
Henriette Van Praag, Tiffany Shubert, Chunmei Zhao, Fred H Gage, None, Exercise Enhances Learning and Hippocampal Neurogenesis in Aged Mice The Journal of Neuroscience. ,vol. 25, pp. 8680- 8685 ,(2005) , 10.1523/JNEUROSCI.1731-05.2005