Sustained ophthalmic delivery of ofloxacin from a pH triggered in situ gelling system
作者： B Srividya , Rita M Cardoza , P.D Amin
DOI: 10.1016/S0168-3659(01)00279-6
关键词: Ofloxacin 、 Biomedical engineering 、 Drug carrier 、 Pharmacology 、 Active ingredient 、 Antibacterial agent 、 Eye drop 、 Chemistry 、 Bioavailability 、 Polyacrylic acid 、 Dosage form
摘要: The poor bioavailability and therapeutic response exhibited by conventional ophthalmic solutions due to rapid precorneal elimination of the drug may be overcome use in situ gel-forming systems that are instilled as drops into eye undergo a sol-gel transition cul-de-sac. present work describes formulation evaluation an delivery system antibacterial agent, ofloxacin, based on concept pH-triggered gelation. Polyacrylic acid (Carbopol 940) was used gelling agent combination with hydroxypropylmethylcellulose (Methocel E50LV) which acted viscosity enhancing agent. developed therapeutically efficacious, stable, non-irritant provided sustained release over 8-h period. is thus viable alternative drops.
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