Salinomycin, a p-glycoprotein inhibitor, sensitizes radiation-treated cancer cells by increasing DNA damage and inducing G2 arrest
作者： Han Sung Kang , Sungpil Yoon , Won Ki Kim , Ju-Hwa Kim , Kyungsil Yoon
DOI: 10.1007/S10637-011-9685-6
关键词: Biology 、 Doxorubicin 、 DNA damage 、 Cancer 、 P-glycoprotein Inhibitor 、 Etoposide 、 Sensitization 、 Cancer cell 、 Pharmacology 、 Salinomycin
摘要: Salinomycin (Sal) is potentially useful for the treatment of cancer. The present study examined a novel mechanism Sal sensitization in cancer cells. sensitized radiation-treated cells by inducing G2 arrest and causing DNA damage. also reduced p21 levels Considering that sensitizes doxorubicin (DOX)- or etoposide (ETO)-treated damage reducing expression, results from our suggest underlying conserved both chemo- We tested ability to inhibit p-glycoprotein (P-gp), which plays role efflux anti-cancer drugs reduce cellular In particular, we compared verapamil (Ver), well-known P-gp inhibitor. inhibits with different substrate distinct Ver. addition, Ver-resistant cells, indicating this compound more effective sensitizing than Taken together, may contribute development Sal-based therapy patients treated P-gp-inhibiting radiation therapy.
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