Vildagliptin Reduces Glucagon during Hyperglycemia and Sustains Glucagon Counterregulation during Hypoglycemia in Type 1 Diabetes

摘要: Context: The dipeptidyl peptidase-4 inhibitor, vildagliptin, inhibits glucagon secretion at hyperglycemia but appears to enhance counterregulation during hypoglycemia in type 2 diabetes. Objective: objective of the investigation was study whether vildagliptin also improves α-cell function 1 diabetes (T1D). Patients and Methods: a single-center, double-blind, randomized, placebo-controlled crossover involving 28 patients with C-peptide negative antibody positive T1D [21 males, seven females, glycosylated hemoglobin 57.9 mmol/mol (7.5%)]. received (50 mg twice day) or placebo as an add-on their insulin therapy for 4 wk each. On d respective treatment period, were served standard meal (500 kcal) raise circulating incretin hormone levels followed by hyperinsulinemic hypoglycemic clamp 2.5 mmol/liter. Main Outcome Measure: increase plasma 30-min (min 1...