Angiotensin II receptor subtypes in the rat brain
作者： Brian P. Rowe , Kevin L. Grove , David L. Saylor , Robert C. Speth
DOI: 10.1016/0014-2999(90)90457-H
关键词: Peptide hormone 、 Angiotensin receptor 、 Binding site 、 Endocrinology 、 Biology 、 Renin–angiotensin system 、 Angiotensin II 、 In vitro 、 Antagonist 、 dup 、 Internal medicine
摘要: Abstract The non-peptide angiotensin II (AII) receptor subtype selective antagonist, DuP 753, was used to characterize AII binding sites in the rat brain. 753 competed for specific 125 I-[Sar 1 , Ile 8 ]AII ( I-SIAII) many brain nuclei (IC 50 = 20−30 nM), but a weak competitor at remaining > 10 −4 M). sensitive (designated α subtype) correspond with areas where is inhibited by sulfhydryl reducing agents, whereas insensitive (AII β ) not agents.
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