Immunohistochemical staining for transforming growth factor beta 1 associates with disease progression in human breast cancer.
作者： Leslie I. Gold , Bradley A. Arrick , Stefan M. Gorsch , Vincent A. Memoli , Thérèse A. Stukel
DOI:
关键词: Transforming growth factor beta 、 Beta (finance) 、 Mammary gland 、 Breast biopsy 、 Estrogen Receptor Status 、 Pathology 、 Cancer 、 Biology 、 Immunohistochemistry 、 Transforming growth factor
摘要: The transforming growth factor beta s (TGF-beta) comprise a family of M(r) 25,000 pluripotent factors which have been implicated in the development and progression human breast cancer. Conflicting data suggest that TGF-beta has potential to either inhibit or promote mammary neoplasia. We therefore examined pathological library malignant biopsy specimens determine prevalence distribution immunoreactivity with antibodies specific for three mammalian isoforms (beta 1, 2, 3). found intense staining 1 was positively associated rate disease progression, this independent age, stage, nodal status, estrogen receptor status (P = 0.009).
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