How complement activation influences the development of chronic synovitis in a mouse model of rheumatoid arthritis.
作者： L Belenska-Todorova , V Gyurkovska , N Ivanovska
DOI: 10.3109/03009742.2015.1036114
关键词: Synovial fluid 、 Synovitis 、 Complement system 、 Inflammation 、 Anaphylatoxin 、 Arthritis 、 Integrin alpha M 、 Zymosan 、 Medicine 、 Immunology
摘要: Objectives: Chronic synovitis is the main characteristic of rheumatoid arthritis (RA), defined by proliferation synovial lining cells, an important source chemokines and cytokines associated with inflammation. The aim this study was to examine influence complement functional activity on development chronic synovitis.Method: experiments were conducted in zymosan-induced (ZIA) provoked intra-articular injection 180 μg zymosan. Mice treated 10 ng/g body weight (bw) cobra venom factor (CVF) days −3 −2 or 10 ng/g bw CVF 7, 12, 17 ZIA. percentage neutrophils (CD11b+Ly6G+), macrophages (F4/80), 5 anaphylatoxin receptor (C5aR)-positive cells fluid (SF) determined flow cytometry expression C5aR C3aR synovium detected immunohistochemically.Results: induction ZIA absence strongly inhibited synovitis. By cont...
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