Three-dimensional models for the study of invasion and metastasis

摘要: Over the last several decades, research into possible causes and preventions of malignant invasion metastasis has vastly increased in scope magnitude. Concurrent with this interest, a number model systems for examination have been presented. The purpose paper is to review related group these evaluate their relevance vivo condition they are intended model. be examined detail three-dimensional culture models, which cellular aggregates fragments, maintained as spherical masses liquid or semi-solid medium, serve substrate by single cells cells. Some models assays malignancy, particularly rate attachment aggregates, aggregation cells, inhibition will discussed briefly. range therefore fairly limited one; however, discussions other systems, some more complex (for example, entire organs studied vitro) others simple monolayer cultures) dealt papers volume.