Refractory neurosarcoidosis responding to infliximab

摘要: Sarcoidosis is an idiopathic inflammatory disease characterized by granulomatous infiltration of multiple organs including the brain. The natural history highly variable and neurologic involvement has been associated with greater resistance to treatment increased overall morbidity mortality.1,2⇓ Corticosteroids are mainstay but adjuvant approaches antimalarials, cyclosporine, cytotoxic agents, anti–tumor necrosis factor-alpha (TNFα) agents thalidomide pentoxifylline have some degree response.3 Increasing evidence suggests that TNFα plays a pivotal role in cascade this disease4,5⇓ recent observations suggest beneficial response refractory systemic sarcoidosis infliximab, chimeric monoclonal human-murine antibody directed against TNFα.6,7⇓ We describe case neurosarcoidosis which patient responded dramatically infliximab therapy. ### Case presentation. A 46-year-old man developed biopsy-proven 16 years previously initially involving skin (lupus pernio) subsequently liver (granulomatous hepatitis), knees (synovitis), lungs (hilar lymphadenopathy), brain (left temporal lobe lesion focal …