Hybrid polyacrylamide chiral stationary phases for HPLC prepared by surface-initiated photopolymerization

摘要: Two hybrid polyacrylamide chiral stationary phases (CSPs) for HPLC have been synthesized by a new surface-initiated photo-induced radical polymerization approach of enantiopure N,N'-diacryloyl derivatives (1R,2R)-diaminocyclohexane (CSP1) and (1R,2R)-diphenylethylenediamine (CSP2). This system is based on the activation mesoporous silica microparticles chemically bonded trichloroacetyl groups dimanganese decacarbonyl as catalyst. UV irradiation was performed using lab-made quartz photochemical reactor, ad hoc designed process surface microparticles. The two were evaluated compared chromatographic supports enantioselective model compounds. Their physico-chemical properties performances also in comparison with those exhibited homologue CSPs obtained grafting-from thermal-induced (CSP3 CSP4). photopolymerization yielded higher grafting density than one, especially case less reactive monomer (the diacryloyl derivative (1R,2R)-diphenylethylenediamine), good efficiency broad application field under normal phase polar organic mode conditions.