Y chromosome probe p49a detects complex PvuII haplotypes and many new TaqI haplotypes in southern African populations.

摘要: Y-specific 49a/TaqI haplotypes were determined for 831 individuals drawn from 21 different southern African populations. A total of 31 new observed, some which contained alleles or allelic variants. Duplication, in addition to CpG mutation, is implicated the generation certain Cluster analysis genetic distances between populations, calculated using haplotype frequencies, revealed a basic split and non-African Hybrid groups cluster with caucasoid groups, indicating that male gene flow has occurred latter into former. Clustering negroid Khoisan not what might have been expected known linguistic affinities. It suggested these populations sufficiently sensitive distinguish many The 49a/PvuII polymorphism was studied 127 17 polymorphic fragments ranging size 3.6 kb greater than 48 identified. 53 PvuII corresponding only 30 TaqI haplotypes. There appears be poor correlation two polymorphisms.