Weissella paramesenteroides WpK4 plays an immunobiotic role in gut-brain axis, reducing gut permeability, anxiety-like and depressive-like behaviors in murine models of colitis and chronic stress

摘要: The relationship between inflammatory bowel disease (IBD) and mood disorders is complex involves overlapping metabolic pathways, which may determine comorbidity. Several studies have been shown that this comorbidity could worsen IBD clinical course. treatment of ulcerative colitis complex, traditional therapy to promote the function epithelial barrier, reducing exacerbated responses. Recently, it has some probiotic strains modulate gut-brain axis, depressive anxiety scores in humans, including patients. Accordingly, study aimed evaluate role Weissella paramesenteroides WpK4 murine models chronic stress. It was observed bacterium ingestion improved health mice, intestinal permeability, besides improving colon histopathological appearance. In stressed bacterial consumption associated with a reduced anxiety-like depressive-like behaviors. both assays, beneficial W. related its immunomodulatory feature. possible state exerted their roles axis through effects consequences several pathways permeability hippocampal physiology.