The PI3K Pathway in Human Disease

作者: David A. Fruman , Honyin Chiu , Benjamin D. Hopkins , Shubha Bagrodia , Lewis C. Cantley

DOI: 10.1016/J.CELL.2017.07.029

关键词: DiseaseFunction (biology)IdelalisibBiologyImmune systemCancerImmunologyBioinformaticsSignal transductionGrowth factor receptorPI3K/AKT/mTOR pathwayGeneral Biochemistry, Genetics and Molecular Biology

摘要: … (PI3K) activity is stimulated by diverse oncogenes and growth factor receptors, and elevated PI3K … We also discuss recent progress developing PI3K-targeted therapies for treatment of …

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