DNA interaction, free radical scavenging and in-vitro antibacterial activity of drug-based copper(II) complexes
作者： Mohan N. Patel , Promise A. Dosi , Bhupesh S. Bhatt
DOI: 10.1002/AOC.1817
关键词: Nuclear chemistry 、 Antibacterial activity 、 DNA 、 Chemistry 、 pUC19 、 Copper 、 Superoxide dismutase 、 Titration 、 Organic chemistry 、 Agarose gel electrophoresis 、 Nucleic acid thermodynamics
摘要: The Cu(II) complexes of type [Cu(cpf)(An)Cl] (An = terpyridines, cpf ciprofloxacin) were synthesized and characterized using IR, mass reflectance spectra. free ligands their evaluated for in-vitro antimicrobial activity against a panel Gram-positive Gram-negative bacteria. exhibit better or equal inhibition in comparison to fluoroquinolones. Binding interactions the with calf thymus (CT DNA) investigated by absorption titration, viscosity studies DNA melting temperature experiment. cleavage reaction on pUC19 was monitored agarose gel electrophoresis. lower concentration catalysed dismutation superoxide radical at biological pH, which indicates that can act as possible model dismutase. Copyright © 2011 John Wiley & Sons, Ltd.
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