Chronic methamphetamine self-administration alters cognitive flexibility in male rats
作者： Brittney M. Cox , Zackary A. Cope , Aram Parsegian , Stan B. Floresco , Gary Aston-Jones
DOI: 10.1007/S00213-016-4283-0
关键词: Psychiatry 、 Drug 、 Methamphetamine 、 Self-administration 、 Clinical psychology 、 Cognitive flexibility 、 Substance abuse 、 Addiction 、 Psychology 、 Meth- 、 Cognition 、 Pharmacology
摘要: Rationale Methamphetamine (meth) addiction is a chronically relapsing disorder that often produces persistent cognitive deficits. These include decreased flexibility, which may prevent meth addicts from altering their habitual drug abuse and leave them more susceptible to relapse. Multiple factors including low rates of compliance with research study participation varied use patterns make the relationship between flexibility relapse difficult establish in clinical populations.
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