Targeting of AML1-ETO in t(8;21) Leukemia by Oridonin Generates a Tumor Suppressor–Like Protein
作者： Tao Zhen , Chuan-Feng Wu , Ping Liu , Hai-Yan Wu , Guang-Biao Zhou
DOI: 10.1126/SCITRANSLMED.3003562
关键词: RUNX1 Translocation Partner 1 Protein 、 Thioredoxin reductase 、 Myeloid leukemia 、 Chromosomal translocation 、 Pharmacology 、 Medicine 、 Myeloid 、 Thioredoxin 、 Apoptosis 、 Cancer research 、 Leukemia
摘要: … cysteines and/or selenocysteines in their active sites (19), we examined whether oridonin … Indeed, TrxR and Trx activities were suppressed by oridonin in Kasumi-1 cells (Fig. 1F). To …
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