Sulindac causes regression of rectal polyps in familial adenomatous polyposis
作者： Denis Labayle , Daniel Fischer , Philippe Vielh , Francois Drouhin , Alex Pariente
DOI: 10.1016/0016-5085(91)90519-Q
关键词: Crossover study 、 Rectum 、 Sulindac 、 Familial adenomatous polyposis 、 Colectomy 、 Rectal Polyp 、 Medicine 、 Placebo 、 Gastroenterology 、 Internal medicine 、 Chemotherapy
摘要: Abstract In familial adenomatous polyposis, sulindac-induced polyp regression has been reported by several authors. this study, the goal was to confirm these results a randomized, placebo-controlled, doubleblind crossover study in 10 patients with rectal polyps that had previously treated colectomy and ileorectal anastomosis. Patients received sulindac, 300 mg/day, or placebo during two 4-month periods separated 1-month wash-out phase. One patient not compliant excluded. With authors observed complete (6 patients) almost (3 of polyps. placebo, an increase (5 patients), no change (2 relative decrease number The difference between sulindac statistically significant ( P
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