Reproducibility of magnetic resonance fingerprinting-based T1 mapping of the healthy prostate at 1.5 and 3.0 T: A proof-of-concept study.

摘要: Facilitating clinical translation of quantitative imaging techniques has been suggested as means improving interobserver agreement and diagnostic accuracy multiparametric magnetic resonance (mpMRI) the prostate. One such technique, fingerprinting (MRF), significant competitive advantages over conventional mapping in terms its multi-site reproducibility, short scanning time inherent robustness to motion. It also shown improve detection clinically prostate cancer when added standard mpMRI sequences, however, existing studies have all conducted on 3.0 T MRI systems, limiting technique's use 1.5 scanners that are still more widely used for across globe. The aim this proof-of-concept study was, therefore, evaluate cross-system reproducibility MRF T1 healthy volunteers (HVs) using systems. initial validation against gold inversion recovery fast spin echo (IR-FSE) ISMRM/NIST system revealed a strong linear correlation between phantom-derived IR-FSE values was observed at both field strengths (R2 = 0.998 1.5T R2 0.993 3T; p < 0.0001 both). In young HVs, inter-scanner CVs demonstrated marginal differences tissues with highest difference 3% fat (2% vs 5% 3T). At strengths, could confidently differentiate peripheral zone from transition zone, which highlights high potential technique given known difficulty tissue differentiation age group. relaxometry preliminary study, supports prospective part larger trials employing routine