Mechanisms of Hepatocellular Dysfunction and Regeneration: Enzyme Inhibition by Nitroimidazole and Human Liver Regeneration

摘要: Enzymes so called (Enz’-a-ai-am) are biologically active protein molecules responsible of biochemical reactions in the bacteria, cells and organs. regulate rates to maintain metabolism keep physiological actions body. High enzyme activities or high cause higher product formation deposits initiate disease. Drugs used as competitors normalize correct Most diseases cured by ‘enzyme inhibition’. Enzyme inhibition can be three types: competitive, non-competitive, uncompetitive. also provides a kind defense regulation inhibit stimulate processes. drugs undergo detoxification biotransformation liver regenerate new hepatocytes Kupffer cells. Major events regeneration regulated enzymes energy metabolism, growth factors cytokine molecules.