Who are the long-term survivors of high grade serous ovarian cancer?

摘要: Although the median survival for epithelial ovarian cancer (EOC) is 10years. A better understanding of these exceptional responders could reveal opportunities to improve dismal prognosis most EOC patients. In this review, we examine clinical and genomic features that have been associated with long-term survival, which generally defined as >7-10years after initial diagnosis. Clinical influencing best reported in large retrospective population-based studies. These studies find previously validated prognostic factors, including younger age at diagnosis, earlier clinicopathologic stage, lower grade, non-serous histology, absence ascites, primary debulking surgery, optimal cytoreduction surgery. Duration a recurrence also contributes depends both on location response subsequent chemotherapy or Germline BRCA mutations, although short-term chemosensitivity, do not appear survival. Unfortunately, relative lack recurrent somatic mutations has made identification signatures difficult. six independent gene expression analyses survivors (LTS) identified prolonged different sets are each study. Genes differentially expressed tumors LTS broadly involved cell proliferation, tumor-stromal interactions, cytoskeleton, metabolism nutrients, immune/stress response. We anticipate consistent selection control groups, combined use emerging transcriptomic, epigenomic, proteomic platforms, likely identify conserved Further elucidating factors contributing potential contribute our biology cancer, goal improving all