Home-Based, Adaptive Cognitive Training for Cognitively Normal Older adults: Initial Efficacy Trial.

作者: Hyun Kyu Lee , James D Kent , Christopher Wendel , Fredric D Wolinsky , Eric D Foster

DOI: 10.1093/GERONB/GBZ073

关键词: Effects of sleep deprivation on cognitive performanceWorking memoryCognitionNeuropsychological testPhysical medicine and rehabilitationCognitive healthCognitive trainingComposite scoreMedicineHome based

摘要: Objectives We examined whether a home-based, adaptive cognitive training (CT) program would lead to performance changes on neuropsychological test battery in cognitively normal older adults. Method Sixty-eight adults (age = 70.0, SD 3.74) were randomly assigned either CT or an active control group (AC, casual computer games). Participants instructed train their programs for 42 min per day, 5 days week, over 10 weeks (35 hr of total usage). completed tests processing speed, working memory, and executive before after training. Results Training groups did not differ After training, participants out-performed AC the overall composite score, driven by speed memory domains. Discussion Our results show that limited dose home-based can drive improvements as measured with battery, suggesting potential health maintenance implications

参考文章(38)
Paul Verhaeghen, Aging and Executive Control: Reports of a Demise Greatly Exaggerated: Current Directions in Psychological Science. ,vol. 20, pp. 174- 180 ,(2011) , 10.1177/0963721411408772
Karlene K. Ball, Lesley A. Ross, David L. Roth, Jerri D. Edwards, Speed of processing training in the ACTIVE study: how much is needed and who benefits? Journal of Aging and Health. ,vol. 25, ,(2013) , 10.1177/0898264312470167
Biswa Sengupta, Simon B. Laughlin, Jeremy E. Niven, Balanced Excitatory and Inhibitory Synaptic Currents Promote Efficient Coding and Metabolic Efficiency PLoS Computational Biology. ,vol. 9, pp. e1003263- ,(2013) , 10.1371/JOURNAL.PCBI.1003263
Po H. Lu, Grace J. Lee, Erika P. Raven, Kathleen Tingus, Theresa Khoo, Paul M. Thompson, George Bartzokis, Age-related slowing in cognitive processing speed is associated with myelin integrity in a very healthy elderly sample Journal of Clinical and Experimental Neuropsychology. ,vol. 33, pp. 1059- 1068 ,(2011) , 10.1080/13803395.2011.595397
Akira Endo, Fumio Nagatani, Chikuma Hamada, Isao Yoshimura, Minimization method for balancing continuous prognostic variables between treatment and control groups using Kullback-Leibler divergence Contemporary Clinical Trials. ,vol. 27, pp. 420- 431 ,(2006) , 10.1016/J.CCT.2006.05.002
Ralph M. Reitan, Validity of the Trail Making Test as an Indicator of Organic Brain Damage Perceptual and Motor Skills. ,vol. 8, pp. 271- 276 ,(1958) , 10.2466/PMS.1958.8.3.271
Michael M. Merzenich, Thomas M. Van Vleet, Mor Nahum, Brain plasticity-based therapeutics Frontiers in Human Neuroscience. ,vol. 8, pp. 385- 385 ,(2014) , 10.3389/FNHUM.2014.00385
Shu-Chen Li, Anna Rieckmann, Neuromodulation and aging: implications of aging neuronal gain control on cognition Current Opinion in Neurobiology. ,vol. 29, pp. 148- 158 ,(2014) , 10.1016/J.CONB.2014.07.009
Pauline L. Baniqued, Michael B. Kranz, Michelle W. Voss, Hyunkyu Lee, Joshua D. Cosman, Joan Severson, Arthur F. Kramer, Cognitive training with casual video games: points to consider Frontiers in Psychology. ,vol. 4, pp. 1010- 1010 ,(2014) , 10.3389/FPSYG.2013.01010
Flavio Donato, Santiago Belluco Rompani, Pico Caroni, None, Parvalbumin-expressing basket-cell network plasticity induced by experience regulates adult learning Nature. ,vol. 504, pp. 272- 276 ,(2013) , 10.1038/NATURE12866