Neural Basis of Pain in Herpes Zoster and Postherpetic Neuralgia: The Ectopic Pacemaker Hypothesis
作者： Marshall Devor
DOI: 10.1007/978-3-319-44348-5_13
关键词: Nociceptor 、 Rash 、 Postherpetic neuralgia 、 Spinal cord 、 Central sensitization 、 Medicine 、 Sensory system 、 Anesthesia
摘要: Pain in herpes zoster and postherpetic neuralgia is classically ascribed to irritable, inflammation-sensitized nociceptors the cutaneous rash spinal cord deafferentation. After considering weaknesses evidence base underlying this view an alternative explanation offered, based on hyperexcitability at ectopic pacemaker sites affected primary sensory neurons, central sensitization induced maintained by activity.
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