Bioactive flavonoids from Kaempferia parviflora
作者： Chavi Yenjai , Khanchara Prasanphen , Supawadee Daodee , Varima Wongpanich , Prasat Kittakoop
DOI: 10.1016/J.FITOTE.2003.08.017
关键词: Pharmacognosy 、 Flavonoid 、 Antimycobacterial 、 Zingiberaceae 、 Rhizome 、 Candida albicans 、 Kaempferia parviflora 、 Pharmacology 、 Biology 、 Phytotherapy
摘要: Nine flavonoids (1-9) have been isolated from Kaempferia parviflora. Among these, 5,7,4'-trimethoxyflavone (8) and 5,7,3',4'-tetramethoxyflavone (9) exhibited antiplasmodial activity against Plasmodium falciparum, with IC50 values of 3.70 4.06 microg/ml, respectively. 3,5,7,4'-Tetramethoxyflavone (7) compound 8 possessed antifungal Candida albicans respective 39.71 17.63 also showed mild antimycobacterial the minimum inhibitory concentrations (MIC) 200 50 However, none compounds demonstrated cytotoxicity KB, BC NCI-H187 cell lines.
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sci-hub.se 参考文章(7)
W Trager, J. Jensen, Human malaria parasites in continuous culture Science. ,vol. 193, pp. 673- 675 ,(1976) , 10.1126/SCIENCE.781840
A. Panthong, D. Kanjanapothi, P. Tuntiwachwuttikul, O. Pancharoen, V. Reutrakul, Antiinflammatory activity of flavonoids. Phytomedicine. ,vol. 1, pp. 141- 144 ,(1994) , 10.1016/S0944-7113(11)80032-2
Tharworn Jaipetch, Vichai Reutrakul, Pittaya Tuntiwachwuttikul, Thawatchai Santisuk, Flavonoids in the black rhizomes of Boesenbergia panduta Phytochemistry. ,vol. 22, pp. 625- 626 ,(1983) , 10.1016/0031-9422(83)83075-1
R E Desjardins, C J Canfield, J D Haynes, J D Chulay, Quantitative assessment of antimalarial activity in vitro by a semiautomated microdilution technique. Antimicrobial Agents and Chemotherapy. ,vol. 16, pp. 710- 718 ,(1979) , 10.1128/AAC.16.6.710
P. Skehan, R. Storeng, D. Scudiero, A. Monks, J. McMahon, D. Vistica, J. T. Warren, H. Bokesch, S. Kenney, M. R. Boyd, New Colorimetric Cytotoxicity Assay for Anticancer-Drug Screening Journal of the National Cancer Institute. ,vol. 82, pp. 1107- 1112 ,(1990) , 10.1093/JNCI/82.13.1107
L Collins, S G Franzblau, Microplate alamar blue assay versus BACTEC 460 system for high-throughput screening of compounds against Mycobacterium tuberculosis and Mycobacterium avium. Antimicrobial Agents and Chemotherapy. ,vol. 41, pp. 1004- 1009 ,(1997) , 10.1128/AAC.41.5.1004
Dominic A. Scudiero, Michael J. Currens, Kenneth D. Paull, Robert H. Shoemaker, Anne Monks, Thomas H. Nofziger, Donna Seniff, Siobhan Tierney, Michael R. Boyd, Evaluation of a Soluble Tetrazolium/Formazan Assay for Cell Growth and Drug Sensitivity in Culture Using Human and Other Tumor Cell Lines Cancer Research. ,vol. 48, pp. 4827- 4833 ,(1988)